Pioglitazone Hydrochloride, Metformin Hydrochloride Oral tablet

What is this medicine?

METFORMIN; PIOGLITAZONE (met FOR min; pye oh GLI ta zone) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • become easily dehydrated

  • bladder cancer

  • diabetic ketoacidosis

  • heart disease

  • if you frequently drink alcohol containing drinks

  • kidney disease

  • liver disease

  • polycystic ovary syndrome

  • serious infection or injury

  • swelling of the arms, legs, or feet

  • undergoing surgery or certain x-ray procedures with injectable contrast agents

  • vomiting

  • an unusual or allergic reaction to metformin, pioglitazone, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • dofetilide

  • gatifloxacin

  • certain contrast medicines given before X-rays, CT scans, MRI, or other procedures

This medicine may also interact with the following medications:

  • atorvastatin

  • digoxin

  • diuretics

  • female hormones, like estrogens or progestins and birth control pills

  • gemfibrozil

  • insulin

  • isoniazid

  • ketoconazole

  • medicines for blood pressure, heart disease, irregular heart beat

  • midazolam

  • morphine

  • niacin

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • phenytoin

  • procainamide

  • quinidine

  • quinine

  • ranitidine

  • rifampin

  • steroid medicines like prednisone or cortisone

  • thyroid hormones

  • trimethoprim

  • vancomycin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them. If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.

If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • blood in the urine

  • breathing problems

  • dark urine

  • feeling faint or lightheaded, falls

  • fever, chills

  • increased urination

  • muscle aches, pains

  • pain when urinating

  • signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness

  • slow or irregular heartbeat

  • stomach pain

  • swelling of the hands, legs, or feet

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • headache

  • heartburn

  • nausea

  • sore throat

  • stuffy or runny nose

  • stomach gas, upset

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture and light. Throw away any unused medicine after the expiration date.

What is this medicine?

METFORMIN; PIOGLITAZONE (met FOR min; pye oh GLI ta zone) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bladder cancer

  • become easily dehydrated

  • diabetic ketoacidosis

  • heart disease

  • if you frequently drink alcohol containing drinks

  • kidney disease

  • liver disease

  • polycystic ovary syndrome

  • serious infection or injury

  • swelling of the arms, legs, or feet

  • undergoing surgery or certain x-ray procedures with injectable contrast agents

  • vomiting

  • an unusual or allergic reaction to metformin, pioglitazone, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Swallow whole, do not crush or chew. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • dofetilide

  • certain contrast medicines given before X-rays, CT scans, MRI, or other procedures

  • gatifloxacin

This medicine may also interact with the following medications:

  • digoxin

  • diuretics

  • female hormones, like estrogens or progestins and birth control pills

  • isoniazid

  • medicines for blood pressure, heart disease, irregular heart beat

  • morphine

  • nicotinic acid

  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine

  • phenytoin

  • procainamide

  • quinidine

  • quinine

  • ranitidine

  • steroid medicines like prednisone or cortisone

  • stimulant medicines for attention disorders, weight loss, or to stay awake

  • thyroid medicines

  • trimethoprim

  • vancomycin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them. If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.

The tablet shell for some brands of this medicine does not dissolve. This is normal. The tablet shell may appear whole in the stool. This is not a cause for concern.

If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • blood in the urine

  • breathing problems

  • feeling faint or lightheaded, falls

  • fever, chills

  • increased urination

  • muscle aches or pains

  • pain when urinating

  • signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness

  • slow or irregular heartbeat

  • unusual stomach pain or discomfort

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • diarrhea

  • headache

  • heartburn

  • metallic taste in mouth

  • nausea

  • sore throat

  • stuffy or runny nose

  • stomach gas, upset

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.